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Alana 0 114 Winnipeg	Irritable Bowel Syndrome and Diet 12/9/2006 9:57:44 PM
	Hopefully this info helps. Probiotics may not work for everyone. Sometimes, you need to try several different types until you find one that works. Here's some studies: NUTRITION RESEARCH REVIEW Study 3: Probiotics reduce bloating --------------------------------------------------- A new US trial investigated the effect of probiotics in irritable bowel patients. Subjects and method: RCT of 48 IBS patients given placebo or probiotic for between 4 and 8 weeks. Results: Probiotic subjects had reduced colonic transit time (p=0.05) and less subjective flatulence (subjective score 29.7 vs 39.5 p= 0.011). Reference: Kim HJ. et al. A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil. 2005 Oct;17(5):687-96. -------------------------------------------------------------------- Those whose digestive tracts tend to play up may be interested in applying the findings of new Study 3 to counter the culinary excesses of the festive season. We have published a number of issues on probiotics 6 and will have more to say on this subject in the new year. The new trial adds to quite a number of studies over some years that, frankly, add up to an encouraging story for a number of GIT disorders. There also seems to be some non-specific effect on immunity that extends beyond the GIT. For example, a recent RCT found that workers in a factory given probiotics (compared with placebo) had 60% less sick days from respiratory tract as well as gastrointestinal diseases 7, and a similar impact on sickness absences was seen in children at a child care centre 8. Of all the nutraceuticals we cover from time to time in this publication, probiotics are the one that your editor finds easiest to recommend in clinical practice. New Study 4 reminds us that many people do not have the luxury of taking a holiday break, focused as they are on the daily task of finding enough food. The new Study is a fresh look at an important topic that we have covered on a number of occasions. That is the potential of zinc (alone or with vitamin A) to reduce child mortality in disadvantaged and malnourished paediatric populations 9. This study is fascinating in that it was a 2 x 2 trial of both zinc and a program to enhance maternal stimulation of young children. The greatest impact on child development scores was seen when both the zinc and the maternal stimulation were given together. Clearly children do not grow by nutrition alone. Finally, for those for whom more vigorous holidays are the order of the day, new Study 5 complements our recent issue on carbohydrate (CHO) in sport in which we reviewed the evidence that management of CHO intake can improve endurance in high intensity exercise 10. The new Study shows that altitude is a significant stressor that makes it important to consume adequate CHO - skiers take note. Incidentally, as we regularly remind our readers whenever we discuss sports nutrition, good hydration is always another important thing to consider. This time of year means many things to many people. Wherever you may live within the 192 countries that our readers are based in, we wish you a peaceful and healthy season of goodwill. References: 1. Helman A. Chocolate and health. Arbor Clinical Nutrition Updates 2003 (Apr);152:1-2 2. Engler MB. et al. Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr. 2004 Jun;23(3):197-204. 3. Mursu J. et al. Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans. Free Radic Biol Med. 2004 Nov 1;37(9):1351-9. 4. Grassi D. et al. Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension. 2005 Aug;46(2):398-405. 5. Samman S. et al. The effect of a lipid-lowering diet on plasma lipids and lipoproteins in mildly hypercholesterolaemic subjects: a potential role for occasional treats. J Nutr Biochem. 2000 May;11(5):250-4. 6. www.nutritionupdates.org/pst/displaytopic.php?cat=46 7. Tubelius P. et al. Increasing work-place healthiness with the probiotic Lactobacillus reuteri: A randomised, double-blind placebo-controlled study. Environ Health. 2005 Nov 7;4:25. 8. Weizman Z. et al. Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics. 2005 Jan;115(1):5-9. 9. www.nutritionupdates.org/pst/displaytopic.php?cat=25 10. Helman A. Carbohydrate and sport Arbor Clinical Nutrition Updates 2003 (Apr);209:1-3 ____________________________________________________ Probiotics show promise in treating colitis CTV.ca News Staff American Journal of Gastroenterology A new Canadian study has found that simple "Probiotic" bacteria are effective in treating ulcerative colitis, a painful disease caused by an immune system attack on the body's intestinal tissue and colon. Researchers at the University of Alberta found six weeks of treatment with pills containing so-called "good" bacteria, or probiotics, can turn the inflamed and bleeding colons of many patients with ulcerative colitis into virtually normal tissue. Probiotics are not new but their healing powers are just starting to be investigated by the medical community. They are the easily obtained bacteria that turn milk into yogurt and are thought to restore intestinal bacteria balance. Patients with colitis often have an overgrowth of "bad" bacteria and not enough of the "good" ones. They experience abdominal pain and bloody diarrhea from inflammation and ulcers in the large bowel. The cause of the illness is unknown though genetic susceptibility is thought to play a role. Researchers tested whether heavy doses of probiotics could help combat the overgrowth of "bad" bacteria in colitis sufferers and help them to heal. They tested 34 patients with mild to moderate active ulcerative colitis who were not responding to conventional therapy. The patients were treated with VSL, a Probiotic mixture containing 450 billion live Probiotic bacteria made up of eight lactic acid bacterial species. Colitis sufferer Joanne Kosowan was diagnosed with the disease 22 years ago. "I was in considerable pain with a lot of bloating, severe cramping and bleeding," she told CTV News. "Yet within a week of being on the probiotics as part of the University of Alberta test I felt better." The study found that the medication brought about a demonstrated remission in 53 per cent of the study group (18 patients), and a favorable response in another 24 per cent (8 patients). There was no response in 9 per cent of patients and a worsening of symptoms in 9 per cent. Two patients did not complete the final assessment. About 30,000 Canadians have ulcerative colitis. Unlike the steroid treatment that many of them endure, the Probiotic treatment caused virtually no side effects, other than mild bloating. "This is a potentially new way of treating inflammatory bowel disease... that is probably quite safe and doesn't have a lot of side effects," says Dr. Hillary Steinhart of Toronto's Mount Sinai Hospital. Doctors don't know why the Probiotic treatment doesn't work on all patients or if its effects are permanent. They also say patients shouldn't self medicate or replace current treatments with probiotics off the store shelf. There is no proof that the doses available in commercial products help symptoms. But they say the study's results are encouraging and probiotics could next be tested on patients with Crohn's disease. The results of the study are published in the latest edition of the American Journal of Gastroenterology _________________________________________________________________________________________ Probiotic Formula Eases IBS Symptoms Posted on: 03/30/2005 NEW YORK--A probiotic preparation containing Bifidobacterium infantis (B. infantis 35624) relieved symptoms in patients suffering irritable bowel syndrome (IBS), according to a study published in the March 2005 issue of Gastroenterology (www2.gastrojournal.org). In the study (128, 3:541-51), Irish researchers gave 77 IBS patients either B. infantis 35624, Lactobacillus salivarius UCC4331 or placebo for eight weeks, and assessed various IBS symptoms daily. B. infantis better alleviated all symptoms--including abdominal pain, bloating and bowel movement difficulty--than the other treatment. Researchers reported subjects’ proinflammatory, Th-1 state was completely normalized by B. infantis feeding alone. They linked the effect to normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for the probiotic strain in IBS patients. In addition, the scientists noted the symptom relief by B. infantis was comparable to effects shown by Zelnorm (tegaserod) and Lotronex (alosetron), two pharmaceuticals recently approved for IBS treatment Our probiotic's Two Acid-Resistant Probiotics Our probiotic contains two probiotic strains – Lactobacillus acidophilus and Bifidobacterium lactis. These probiotics are strong enough to endure you stomach acid, pass through the digestive process, and enter your large intestine where they go to work balancing intestinal flora. Our probiotics were put through extensive tests in collaboration with the Institute Pasteur in Lille, France – the world’s most prestigious biological research laboratories. Each strain underwent in vivo (in the body) to verify the effectiveness of the lab tests and to ensure Florify’s probiotics improve nutrient uptake and balance the negative effects of the bad flora in your intestine. Our probiotics are not unknown to your body. They are normal inhabitants of a healthy intestine. Lactobacillus acidophilus targets the upper part of your GI tract – you stomach, duodenum, jejunum, and ileum. Bifidobacterium lactis works on the lower part of your GI tract – the large intestine. When our probiotics are introduced into your body, they establish a rapport with the other bacteria that naturally reside there. They attach themselves to the intestine wall where they help counteract the negative effects of harmful flora. Studies show Lactobacillus acidophilus and Bifidobacterium lactis maintain a healthy balance of intestinal flora by producing organic compounds like lactic acid, hydrogen peroxide, and acetic acid. These acids naturally increase the acidity of the intestine and inhibit the reproduction of many harmful flora. These probiotics also produce substances called bacteriocins, which act as natural antibiotics to kill undesirable microorganisms. Our probiotics persist only as long as they are continually ingested. Florify, with the research-recommended 5 billion colonies, must be taken consistently in order to increase and maintain the number of beneficial flora in your system. Alana

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Donna 1764 2077 Logans...	Re: Irritable Bowel Syndrome and Diet 12/11/2006 1:05:46 AM
	Thanks Tom. I am glad to see it has so many strains of probiotics. The FOS is good too. It was in a capsule I used to take from a health company of which I am a representative but they discontinued the probiotic capsules for some reason and came out with a powdered probiotic that does not mix well with liquids and is not as good as the capsule. (Although I still had problems with IBS even with their capsule). Only recently did I become aware of how many strains of probiotics there are. Perhaps some work better for certain individuals than others. It is probably a matter of trial and error. I have tried several brands of probiotics and have not had the results I expected and hoped for. One of them had L. acidophilus and B. longum plus proprietary digestive enzymes. The other has Lactobacillus acidophilus DDS-1, Lactobacillus bulgaricus, Lactobacillus cases, Streptococcus thermophilus, Bifidobacteruim longum, and Lactobacillus acidophilus. Your probiotic has similar strains to this one but not all are the same. How confusing this can be in trying to figure out exactly which strains are valuable for IBS. DonnaZ
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Donna

1764

2077

Logans...

Re: Irritable Bowel Syndrome and Diet

12/11/2006 1:13:16 AM

Thanks for all the interesting articles on probiotics Alana. I noticed I do have a bottle of the Florifly but haven't taken it consistently (sigh) so will order a new bottle and try it out.

I just found another article on a study done in Finland and will paste it here.

Breaking News on Supplements & Nutrition - Europe

Previous page : Can prebiotics protect probiotics during processing?

Can prebiotics protect probiotics during processing?

By Stephen Daniells

08/12/2006- Using prebiotics as carriers could protect probiotics during processing and storage, as well imparting their own beneficial effects in the finished product, suggests new research from Finland.

Scientists from the Technical Research Centre of Finland (VTT) investigated the capabilities of various prebiotic fibres to protect the stability and viability of probiotic Lactobacillus rhamnosus strains during freeze-drying, storage in freeze-dried form and after formulation into apple juice and chocolate-coated breakfast cereals.

“The present study indicated that some fibre preparations have the potential in technological applications in protecting probiotic viability and stability during processing and storage in food matrices,” wrote lead author Maria Saarela in the International Journal of Food Microbiology.

“Currently food products combining probiotics with prebiotics or fibres are gaining more interest and are introduced into the market. These kinds of products would attain added value if the fibre could protect probiotic cells during down-stream processing, formulation and/or storage and thus improve their viability and stability.”

Most foods containing probiotic bacteria are found in the refrigerated section of supermarkets as the bacteria is destroyed by heat and other processing conditions.

This has given the dairy sector, already used to handling live bacteria for the manufacture of yoghurt, a major advantage in probiotic foods - probiotic drinking yoghurts are currently the fastest growing dairy product in Europe.

But increasing research has focused on expanding protecting probiotics during processing and expanding the food categories available to prebiotics. Such an avenue of research has led companies like Cell Biotech from Korea using a dual-coating to protect probiotics against oxygen, acid, moisture and high temperatures for use in emerging new product categories such as breakfast cereals and smoothies.

Maria Saarela told NutraIngredients.com that by choosing the right combination of pre- and probiotic the stability of the latter could be enhanced for a specific application.

“If the fibre effect is also wanted, then more of the same carrier substrate can be added directly into the product,” she said.

Focussing on the L. rhamnosus strains E-97800 (E800) and E-94522 (E522) from VTT culture collection, probiotic-prebiotic pairs were prepared with a range of fibres, including oat flour (10 and 20 per cent beta-glucan, Natureal, Suomen Viljava Oy), apple fibre, wheat dextrin (Nutriose FB, Roquette), polydextrose (Litesse, Danisco) and inulin (Raftiline, Orafti).

“Skim milk supplemented with polydextrose has been used to spray-dry probiotics, but with fairly poor results (regarding the addition of polydextrose),” said Saarela. “Wheat dextrin and oat flour have not been studied before, as far as I know.”

The VTT researchers report that different adhesion properties of the probiotic strains to the various fibre preparations, with the L. rhamnosus E800 found to be highly adherent, while E522 adhesion was relatively poor.

“Good adhesion to fibre preparations is not a common feature among lactic acid bacteria,” said the researchers.

They also said that, of all the fibre carriers studied, wheat dextrin and polydextrose had the most potential as carriers for the L. rhamnosus strains for freeze-drying, with both survival and storage stability at 37 degrees Celsius reported to be comparable to the sucrose control carrier.

When incorporated into the chocolate-coated breakfast cereals, the researchers reported that wheat dextrin and polydextrose again proved to be better carriers.

However, when formulated into the low pH apple juice (pH3.5) the oat flour with 20 per cent beta-glucan showed the best potential for carriers of fresh probiotic cells during storage.

“Perhaps the main finding in this study was that different fibres can be used in different applications: polydextrose and dextrin were good freeze-drying carriers and for dry applications whereas oat rich in beta-glucan was a good carrier for fresh cells in apple juice,” Saarela told this website.

The study was funded by the National Technology Agency of Finland, and as part of the European Commission’s RTD programme, “Quality of Life and Management of Living Resources”.

Source: International Journal of Food Microbiology
November 2006, Volume 112, Issue 2, Pages 171-178
“Fibres as carriers for Lactobacillus rhamnosus during freeze-drying and storage in apple juice and chocolate-coated breakfast cereals”
Authors: M. Saarela, I. Virkajärvi, L. Nohynek, A. Vaari and J. Mättö

DonnaZ

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Donna

1764

2077

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Re: Irritable Bowel Syndrome and Diet

12/11/2006 1:34:00 AM

Here is another article I just found on probiotics possible help for IBS symptoms.

Probiotic may help manage IBS symptoms, says Institut Rosell


	Related News Probiotic bacteria helps irritable bowel syndrome Suppliers identify solutions for new probiotic foods Scientific support needed to tap probiotics potential

7/7/2005 - A probiotic formulation developed by French/Canadian company Institut Rosell reduced symptoms associated with IBS in tests on a rat model, writes Dominique Patton.

The company reported the findings at a symposium on neurogasterentology and motility, taking place this week in Toulouse, France.

Researchers at INRA and the Pierre Fabre Research Institute tested the formulation called Lacidofil (Lactobacillus acidophilus rosell-52 and Lactobacillus rhamnosus Rosell-11) on two common IBS symptoms, that were induced in rats through stress - increase in colonic permeability and hypersensitivity of the gut.

Henri Durand, scientific director at Institut Rosell, told NutraIngredients.com that the findings confirmed previous research showing that some strains can act against this type of disease.

In March a team from the Alimentary Pharmabiotic Centre at Ireland’s University College Cork reported that IBS patients who consumed a malted milk drink containing the Bifidobacterium infantis 35624 bacteria everyday for eight weeks experienced fewer overall symptoms, abdominal pain and discomfort.

IBS is a long-term condition that usually involves cramping, diarrhoea and constipation. It affects between 10 and 15 per cent of the Irish population and a similar proportion of people in other western countries.

However the precise cause of IBS is not fully understood and there is no cure yet. Treatments are aimed at alleviating symptoms but medication, for those with moderate to severe forms of the disease, does not work for all patients.

Preliminary science has suggested the potential of probiotic bacteria to protect the gut against the condition, although there are only a handful of probiotic products on the market claiming to target the condition.

The French study used two rat models that have been designed by a Toulouse lab to measure the sensitivity and function of gut health.

In the first, scientists implant electrodes into the abdomen muscles of the animals to measure contractions in response to a balloon inserted into the rectum. Increasing the volume usually causes hypersensitivity but in animals pre-treated with the probiotic formulation, no increase in sensitivity was observed, said Durand.

“This is a well-accepted model for gut sensitivity,” he said.

A second experiment measured the permeability of the gut after a stressful situation (restraint of the rats). Inflammation of the gut, a common IBS symptom, increases the permeability of the gut and therefore risk of infection.

The French team tested the strength of the gut wall by looking at how much of a chromium compound could be recovered in the urine.

Again, the probiotic rats were found to have higher protection against increased gut permeability.

“This is a promising step. We are planning a human study to verify these findings,” said Durand. It is likely to start by the end of the year.

The Rosell probiotic is currently used against diarrhoea, another IBS symptom, in markets including central and eastern Europe, the US and Canada.

DonnaZ

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