HIV is the culprit for AIDS, the disease against which no effective treatment option is established yet. Here is easy explanation how HIV is damaging our cells of immune system.

HIV has infected more than 60 million and killed neary 30 million people around the world. Every day in an infected person the HIV destroys billions of infection-fighting CD4+ T cells, until the immune system is no longer able to regenerate or fight other infections.

The virus does this in several ways. One way is by killing cells directly: it hijacks cells and uses their resources to make copies of itself. These copies emerge as buds that burst through the cell membrane, killing the cell in the process. Another way HIV kills the host cell directly is just by exhausting its resources.

And another way that causes host cells to die, is when the host cell machinery becomes grossly distorted from being used to make virus copies, this can trigger a process known as programmed cell death or apoptosis.

When HIV enters the host cell, it starts reprogramming its protein-building machinery by inserting its own genes into the cellular DNA.

It is discovered that during this insertion step, a cellular enzyme called DNA-dependent protein kinase (DNA-PK) becomes active. The enzyme normally helps repair double-stranded breaks in molecules that make up DNA.

But when HIV integrates its genes into host cell DNA, this results in single-stranded breaks at the insertion points.

It is found that the DNA breaks occuring during HIV integration activates DNA-PK, which then performs an unusually destructive role: it triggers a signal that causes apoptosis in the CD4+ T cell.

Great info, thanks Hafiz

Bee Venom Destroys HIV And Spares Surrounding Cells

Nanoparticles containing bee venom toxin melittin can destroy human immunodeficiency virus (HIV) while at the same time leaving surrounding cells unharmed, scientists from Washington University School of Medicine reported in the March 2013 issue of Antiviral Therapy.

The researchers said that their finding is a major step toward creating a vaginal gel that can prevent HIV spread. HIV is the virus that causes AIDS.

Joshua L. Hood, MD, PhD, a research instructor in medicine, said:

"Our hope is that in places where HIV is running rampant, people could use this gel as a preventive measure to stop the initial infection."

Melittin destroys some viruses and malignant tumor cells

Melittin is a powerful toxin found in bee venom. It can poke holes in the protective viral envelope that surrounds the human immunodeficiency virus, as well as other viruses. Free melittin in large-enough quantities can cause considerable damage.

Senior author, Samuel A. Wickline, MD, the J. Russell Hornsby Professor of Biomedical Sciences, has demonstrated that nanoparticles loaded with melittin have anti-cancer properties and have the capacity to kill tumor cells. Linking bee venom with anticancer therapies is not new, in 2004 Croatian scientists reported in the Journal of the Science of Food and Agriculture that honey-bee products, including venom, could well have applications in cancer treatment and prevention.

Normal cells remain intact :
The scientists showed that nanoparticles loaded with melittin do not harm normal, healthy cells. Protective bumpers were added to the nanoparticles surface, so that when they come into contact with normal cells (which tend to be much larger), the nanoparticles bounce off rather than attach themselves.


HIV is much smaller than the nanoparticles and fits in between the bumpers. When HIV comes across a nanoparticle it goes in between the bumpers and comes into direct contact with its surface, which is coated with the bee toxin, which destroys it.

Hood explained "Melittin on the nanoparticles fuses with the viral envelope. The melittin forms little pore-like attack complexes and ruptures the envelope, stripping it off the virus."

While most anti-HIV medications work on inhibiting the virus' ability to replicate, this one attacks a vital part of its structure. The problem with attacking a pathogen's ability to replicate is that it does not stop it from starting an infection. Some HIV strains have found ways to circumvent replication-inhibiting drugs, and reproduce regardless.

Hood said:

"We are attacking an inherent physical property of HIV. Theoretically, there isn't any way for the virus to adapt to that. The virus has to have a protective coat, a double-layered membrane that covers the virus."

Melittin nanoparticles may prevent and treat existing HIV infections

Hood believes that the melittin-loaded nanoparticles have the potential for two types of therapies:

• A vaginal gel to prevent the spread of HIV infection
• Therapy for existing HIV infections, particularly drug-resistant ones

In theory, if the nanoparticles were injected into the patient's bloodstream, they should be able to clear the blood of HIV.

Hood said "The basic particle that we are using in these experiments was developed many years ago as an artificial blood product. It didn't work very well for delivering oxygen, but it circulates safely in the body and gives us a nice platform that we can adapt to fight different kinds of infections."

Melittin attacks double-layered membranes indiscriminately, making it a potential for drug therapies beyond HIV infections. The hepatitis B and C viruses, among several others, rely on the same type of protective envelope and could be targeted and destroyed by administering melittin-loaded nanoparticles.

The gel also has the potential to target sperm, the researchers explained, making it a possible contraceptive medication. The study, however, did not look at contraception.

Hood said "We also are looking at this for couples where only one of the partners has HIV, and they want to have a baby. These particles by themselves are actually very safe for sperm, for the same reason they are safe for vaginal cells."

This study was carried out in cells in a laboratory environment. However, the nanoparticles are easy to produce - enough of them could easily be supplied for future human studies.

What is the difference between HIV and AIDS?

HIV is the virus which attacks the T-cells in the immune system.

AIDS is the syndrome which appears in advanced stages of HIV infection.

HIV is a virus.

AIDS is a medical condition.

HIV infection causes AIDS to develop. However, it is possible to be infected with HIV without developing AIDS. Without treatment, the HIV infection is allowed to progress and eventually it will develop into AIDS in the vast majority of cases.

HIV testing can identify infection in the early stages. This allows the patient to use prophylactic (preventive) drugs which will slow the rate at which the virus replicates, delaying the onset of AIDS.

AIDS patients still have the HIV virus and are still infectious. Someone with AIDS can pass HIV to someone else.